Horror based on a story by famed horror writer Edgar Allan Poe. The film is set in an insane asylum presided over by notorious brigand, Raul Fragonard (Claudio Brook). He has locked up the institution's director and set the lunatics free. A visting journalist uncovers the secret behind the Mansion of Madness, but soon finds himself on trial before a host of crazed lunatics - whose ultimate aim is world domination.
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