Emerging targets in antibacterial and antifungal chemotherapy - Joyce A Sutcliffe

Emerging Targets in Antibacterial and Antifungal Chemotherapy
offers constructive ideas to researchers that could lead to the
discovery of
entirely new classes of drugs. The authors emphasize new
topics
rather than review work on known antibacterials and
antifungals, and
identify new targets--either the rate-limiting
component of a
biochemical pathway or a component of the pathway that
is susceptible
to a ``screening'' or ``rational drug design''
approach. Each chapter
reviews the biochemical pathway and its place
in the cellular scheme
in order to place the target in perspective.
The authors, a mixture
of academic researchers and drug-discovery
investigators in
pharmaceutical companies, also extend these
theoretical concerns into
practical applications and suggest useful
screening methodologies.
The importance of this subject area is
demonstrated by the increasing
number of papers in the literature
that point to potential targets
and screening methodologies for new
antibacterials. This book also
deals with antifungals, investigating
the inherent limitations in
existing antifungals (many of which are
extremely toxic or have only
limited efficacy), and pointing to major
developments in the
discovery of novel antifungals. Emerging Targets
in Antibacterial and
Antifungal Chemotherapy will be of interest to
professional
microbiologists, biochemists, and cell biologists in
both academic
and industrial laboratories.