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Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity - Franck Mauvais-Jarvis
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Title
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
Author
Franck Mauvais-Jarvis
Franck Mauvais-Jarvis
format
Hardback
Hardback
Publisher
Springer
Springer
Language
English
English
UK Publication Date
20180109
20180109
Description
The book provides areference for years to come, written by world-renowned expert investigators studying sex differences, therole of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes tometabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views onsex-specific drug discovery. Many of the authors presented at the Keystone Symposium on "Sex and gender factors affecting metabolic homeostasis, diabetes and obesity" to be held inMarch 2017 in Lake Tahoe, CA. This book will generate newknowledge and ideas on the importance of gender biology and medicine from a molecular standpoint tothe population level and to provide the methods to study them. It is intended to be acatalyst leading to gender-specific treatments of metabolic diseases.
There are fundamental aspects of metabolic homeostasis that are regulated differently in males
andfemales, and influence both the development of diabetes and obesity and the response topharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to theadded complexity of research plans. The consequence is a generation of data that risks being relevantto only half of the population. This is a timely moment to publish a book on sex differences in diseases asNIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensurethat women get the same benefit of medical research as men.
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